Obsessive Compulsive Disorder

Epidemiology

Comorbidity

OCD and Tic Disorder

OCD and Depression

OCD and Other Anxiety Disorders

OCD and Phobia

OCD and OCPD

OCD and Schizophrenia

Course and Prognosis

Etiology

Specific Clinical Response

Serotonin Antagonists

Pharmacological Challenges

Dopamine

Immune Factors

Brain Imaging Studies

Genetics

Other Biological Data

Behavioral Factors

Psychosocial Factors

Treatment of OCD

Efficacy of Serotonergic vs Adrenergic Antidepressants

Long Term Treatment of OCD

Drug Dosage

Psychological Approaches

Treatment Resistant OCD

Switching Medications

Augmentation

Risperidone

Pindolol

Other Options

Intravenous Clomipramine

Monoamine Oxidase Inhibitors

Last-line Therapies

Overcoming Anxiety (Home) > Obsessive Compulsive Disorder > Augmentation

Augmentation for Obsessive Compulsive Disorder

Augmentation is called for when there is partial or no response to the abovementioned approaches, i.e. combination of SSRIs (or SRIs) with other medications. To date, only two augmenting agents have been found to be effective in double-blind studies, i.e., risperidone and pindolol, which will be discussed below. However, many other augmenting agents have been tried and may be effective for some refractory patients. These include buspirone, lithium, trazodone, tryptophan and thyroid hormones.




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