Augmentation is called for when there is partial or no response to the abovementioned approaches, i.e. combination of SSRIs (or SRIs) with other medications. To date, only two augmenting agents have been found to be effective in double-blind studies, i.e., risperidone and pindolol, which will be discussed below. However, many other augmenting agents have been tried and may be effective for some refractory patients. These include buspirone, lithium, trazodone, tryptophan and thyroid hormones.

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