The efficacy of the SSRIs for OCD, together with the lack of efficacy of adrenergic antidepressants, has suggested that serotonin is involved in the pathophysiology of OCD. This relationship was validated by research on serotonergic markers in OCD and by the challenge paradigm. It is still unclear which type of serotonergic receptor is involved in the pathogenesis and mechanism of action of antiobsessional drugs. Further studies of the serotonergic system in OCD may clarify the role of serotonin in the athophysiology and management of OCD.

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