Obsessive Compulsive Disorder

Epidemiology

Comorbidity

OCD and Tic Disorder

OCD and Depression

OCD and Other Anxiety Disorders

OCD and Phobia

OCD and OCPD

OCD and Schizophrenia

Course and Prognosis

Etiology

Specific Clinical Response

Serotonin Antagonists

Pharmacological Challenges

Dopamine

Immune Factors

Brain Imaging Studies

Genetics

Other Biological Data

Behavioral Factors

Psychosocial Factors

Treatment of OCD

Efficacy of Serotonergic vs Adrenergic Antidepressants

Long Term Treatment of OCD

Drug Dosage

Psychological Approaches

Treatment Resistant OCD

Switching Medications

Augmentation

Risperidone

Pindolol

Other Options

Intravenous Clomipramine

Monoamine Oxidase Inhibitors

Last-line Therapies

Overcoming Anxiety (Home) > Obsessive Compulsive Disorder > Etiology

Etiology for Obsessive Compulsive Disorder

Personality disorder, Dissociative Identity Disorder

The efficacy of the SSRIs for OCD, together with the lack of efficacy of adrenergic antidepressants, has suggested that serotonin is involved in the pathophysiology of OCD. This relationship was validated by research on serotonergic markers in OCD and by the challenge paradigm. It is still unclear which type of serotonergic receptor is involved in the pathogenesis and mechanism of action of antiobsessional drugs. Further studies of the serotonergic system in OCD may clarify the role of serotonin in the athophysiology and management of OCD.




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