Obsessive Compulsive Disorder
- Epidemiology
- Comorbidity
- OCD and Tic Disorder
- OCD and Depression
- OCD and Other Anxiety Disorders
- OCD and Phobia
- OCD and OCPD
- OCD and Schizophrenia
- Course and Prognosis
- Etiology
- Specific Clinical Response
- Serotonin Antagonists
- Pharmacological Challenges
- Dopamine
- Immune Factors
- Brain Imaging Studies
- Genetics
- Other Biological Data
- Behavioral Factors
- Psychosocial Factors
- Treatment of OCD
- Efficacy of Serotonergic vs Adrenergic Antidepressants
- Long Term Treatment of OCD
- Drug Dosage
- Psychological Approaches
- Treatment Resistant OCD
- Switching Medications
- Augmentation
- Risperidone
- Pindolol
- Other Options
- Intravenous Clomipramine
- Monoamine Oxidase Inhibitors
- Last-line Therapies
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Genetics for Obsessive Compulsive Disorder: Human and Bipolar Anxiety Disorders
A significantly higher concordance rate was found for monozygotic twins than for dizygotic twins . Some 35% of the first-degree relatives of childhood-onset OCD patients are also afflicted with the disorder . Although this high rate is possibly related to the early onset subtype, it nevertheless suggests a genetic component in OCD. Genetic research has yet to find abnormalities at the 5-HT transporter gene level. A study exploring the polymorphism of the promoter region of the gene for the 5-HT transporter failed to identify any differences between OCD patients and controls.