Obsessive Compulsive Disorder

Epidemiology

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OCD and Tic Disorder

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Intravenous Clomipramine

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Overcoming Anxiety (Home) > Obsessive Compulsive Disorder > OCD and Depression

OCD and Depression

Depression is the most common complication of OCD and by recognizing this relationship, DSM-IV no longer excludes a diagnosis ofOCDif depression is present. Instead, it stipulates that the obsession may not be related in content to the guiltridden rumination of major depression. However, a precise definition of the relationship between OCD and depression remains elusive. At the clinical level, the illnesses often seem inseparable—one worsening or improving in synchrony with the other.

However, in other clinical cases, OCD symptoms may remain in remission while depression recurs. Although researchers have reported some similarities in the biological markers for depression and OCD, the differences between the two outweigh their similarities . The most striking difference is that antidepressants with excellent efficacy, such as the noradrenergic re-uptake inhibitor desipramine, appear to be totally ineffective in the treatment of OCD . Only medications possessing serotonergic properties, such as clomipramine, fluoxetine, fluvoxamine, paroxetine, sertraline and citalopram, have consistent efficacy in reducing OCD symptoms. Other differences relate again to the lack of therapeutic effect of electroconvulsive therapy (ECT) or lithium augmentation in OCD, as compared with their proven efficacy in depression.

	More Articles
1. Specific Clinical Response for OCD Specific Clinical Response for OCD Reports that clomipramine (CMI), a tricyclic antidepressant with a serotonergic profile, is effective in treating symptoms of OCD has directed researchers’ interest in the relationship between [...]
2. Provocative Agents Provocative Agents Intravenous infusion of sodium lactate 0.5–1M has been reported to reliably induce panic attacks in PD patients . Twenty minutes [...]
3. Recognizing and Curing Depression and Anxiety Disorder Curing Depression and Anxiety Disorder Depression and anxiety disorders are suffered by way to many people out there. Women are usually not treated [...]
4. Augmentation for Obsessive Compulsive Disorder Augmentation for Obsessive Compulsive Disorder Augmentation is called for when there is partial or no response to the abovementioned approaches, i.e. [...]

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