Obsessive Compulsive Disorder

Epidemiology

Comorbidity

OCD and Tic Disorder

OCD and Depression

OCD and Other Anxiety Disorders

OCD and Phobia

OCD and OCPD

OCD and Schizophrenia

Course and Prognosis

Etiology

Specific Clinical Response

Serotonin Antagonists

Pharmacological Challenges

Dopamine

Immune Factors

Brain Imaging Studies

Genetics

Other Biological Data

Behavioral Factors

Psychosocial Factors

Treatment of OCD

Efficacy of Serotonergic vs Adrenergic Antidepressants

Long Term Treatment of OCD

Drug Dosage

Psychological Approaches

Treatment Resistant OCD

Switching Medications

Augmentation

Risperidone

Pindolol

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Intravenous Clomipramine

Monoamine Oxidase Inhibitors

Last-line Therapies

Overcoming Anxiety (Home) > Obsessive Compulsive Disorder > OCD and Schizophrenia

OCD and Schizophrenia

About 10% to 25% of chronic schizophrenia patients may also present with OCD symptoms (range 5–45%) , and 15% may qualify for the diagnosis of OCD. As in OCD, the OCD symptoms in these patients will not necessarily surface unless specific questions are asked. Many patients with schizophrenia can distinguish the ego-dystonic OC symptoms, perceived as coming from within, from the ego-syntonic delusions perceived as intruding from the outside. Follow-up studies demonstrate diagnostic stability over time and it seems that the presence of OCD in schizophrenia predicts a poor prognosis. Several studies among patients with schizophrenia and OCD reported an improvement in OCD symptomatology after the addition of a specific antiobsessive medication (ibid).

Due to the different (poorer) prognosis of patients with schizo-obsessive symptoms, as well as preliminary data regarding their response to specific therapeutic intervention (i.e., the combination of antipsychotic and antiobsessive medications), and taking into account the high prevalence of this presentation, several researchers have suggested that a ‘‘schizo-obsessive’’ category may be considered.

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