Obsessive Compulsive Disorder

Epidemiology

Comorbidity

OCD and Tic Disorder

OCD and Depression

OCD and Other Anxiety Disorders

OCD and Phobia

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Specific Clinical Response

Serotonin Antagonists

Pharmacological Challenges

Dopamine

Immune Factors

Brain Imaging Studies

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Behavioral Factors

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Treatment of OCD

Efficacy of Serotonergic vs Adrenergic Antidepressants

Long Term Treatment of OCD

Drug Dosage

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Treatment Resistant OCD

Switching Medications

Augmentation

Risperidone

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Intravenous Clomipramine

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Overcoming Anxiety (Home) > Obsessive Compulsive Disorder > Specific Clinical Response

Specific Clinical Response for OCD

Reports that clomipramine (CMI), a tricyclic antidepressant with a serotonergic profile, is effective in treating symptoms of OCD has directed researchers’ interest in the relationship between serotonin and OCD. Moreover, OCD is currently unique among psychiatric disorders, as only serotonergic medications appear to be effective in this disorder. For example, non-serotonergic drugs, such as desipramine (DMI), which are effective in depression and panic disorder, are entirely ineffective in OCD. While this does not necessarily reflect on pathogenesis, the specific response to serotonergic drugs has paved the way for further research on the role of serotonin in the pathogenesis of OCD in particular, and in OCD-related disorders in general. As yet, abnormality of the serotonergic system and particularly hypersensitivity of post-synaptic 5-HT (hydroxy tryptamine) receptors, constitute the leading hypothesis for the underlying pathophysiology of OCD.

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